DNA repair mechanisms role in survival to nucleoside analogues Thesis

DNA repair mechanisms role in survival to nucleoside analogues treatment in S.pombe - Thesis Example Two methods of treatment where this is especially important to consider are topoisomerase inhibitors and nucleoside analogues. In both of these cases, DNA repair systems involve the use of the Mre11/Rad50/NBS1 complex. This project aims to examine how DNA repair mechanisms of Schizosaccharomyces pombe contribute to resistance to treatment with nucleoside analogues. This information should help to provide further insight into the way in which human cells are able to develop resistance to this form of treatment, and perhaps provide some indication of a method to prevent this. In everyday life, cells are exposed to external and internal agents that cause thousands of DNA mutations per day. These mutations range from being small, such as affecting a single nucleotide, to large mutations where accurate repair can be difficult. For the accurate propagation of the genetic information within cells, it is essential that the body has mechanisms of repairing damage in a reliable manner. However, while many methods for DNA repair exist, these are not always successful and mutations can accumulate, resulting in the development of cancer (Helleday et al., 2007). Understanding these processes, why they occur the way that they do and what can be done to influence these is crucial for knowing the way that cancer occurs, and determining methods of treating it effectively. In our modern society, cancer has remained one of the most well studied diseases and perhaps one of the least understood. The fundamental aspects of cancer are damage in the DNA of a cell that results in a lack of control over cell growth and replication, as well reducing the likelihood that cells will enter apoptosis. These cells are able to proliferate well beyond the normal constraints of the tissue that they are in (Loeb et al., 2003). With high levels of replication and low cell death, abnormal cells build up

Web Site Evaluation Paper Essay Example | Topics and Well Written Essays - 750 words

Web Site Evaluation Paper - Essay Example The essay "Web Site Evaluation Paper" discovers the evaluation of Forbes website. The website defines the credentials of the author by showing that he was part of the Great Premium Content Experiment at AOL as a media columnist for the business website Daily Finance. As such, he has authority and credibility to author this web page. Moreover, the introductory materials reveal that the author was motivated to publish this information on the web. In fact, the author claims that he would be bored if things were not different which means he is motivated to publish this information on the web. Ultimately, the website provides the contact information of the author by offering his email address, his twitter account, and his Google account, which means that the audience can respond to his works and interact with him freely. The website’s purpose to inform, explain, or persuade is very clear. The title of the website reflects a clear opinion that the website seeks to pass to the target audience. The title, â€Å"Larry Page: Google Should Be Thinking Bigger with Its R&D† reflects a clear purpose to inform, and persuade the audience. Indeed, the site is explicit, as the title leaves no room for confusion or doubt about the author’s point of view. In fact, the website starts by introducing the author’s points of concern, which are some of the blue-sky products that Google is developing now. The website indicates clearly that the author has an affiliation with a specific organization by asserting that Jeff Bercovici is Forbes. staff. It goes ahead to give the organization’s domain as part of the author’s contact information by giving his email as jbercovici@forbes.com (Bercovici 1). Most of all, the website does not indicate its specific audience since it claims the author covers media, business, entertainment, and technology. We can establish that the topic covered by the website is very clear since it is explicit. However, part of the audience might not know what the initials R&D mean in this context and hence some ambiguity. The website equally uses an easy language to present the relevant information discussing the topic and thus its clarity and effectiveness. Notably, the site exhibits suitable depth and comprehensiveness to fulfill its purpose. To this effect, the website uses relevant information, presents the inner and crucial details of the company in reference, quotes the views of relevant business leaders (Bercovici 1), and integrates all pieces of information to support the author’s view. Indeed, the information presented by the website clearly supports the opinion of the author. It uses historical evidence like when it quotes the example of Google’s massive success in mobile (Bercovici 1). It also quotes the actual words of Google CEO, Larry Page who sought to persuade investors on the viability of the current project. The website clearly states the sources of information and we can indeed ascertain that the information is original. This is because the author uses direct quotes to state what

Penn Foster Exam Essay Example for Free

Penn Foster Exam Essay Paragraph 1 I’m replying to your career opportunity posted on your website. I understand that you are actively seeking to hire a Medical Coding and Billing Specialist at one of your Dartmouth Hitchcock locations. This position is responsible for reviewing medical records of discharged patients to ensure that diagnoses and procedures have been recorded; collect, code and compile medical record data for future retrieval, reports and reimbursement purposes. My granddaughter passed away about a year and a half ago. She was air-lifted to one of your locations upon birth where the doctors and nurses tried everything they could to save her; however she died. Through that experience, though, I saw how your employees, handled a very difficult situation, and the nurses and doctors inspired me with their compassion. The Health Care industry has always been a dream of mine, and I decided to pursue a career in Medical Coding and Billing with Penn Foster University. As a Medical Coding and Billing Specialist within your company, I am confident that I could make a valuable contribution to the medical team serving your patients and insurance companies in a timely and professional manner. Paragraph 2 My boss, Ms. Levine has a position available for an assistant here at Northeast Propane. I think this would be an excellent job opportunity for you. From your previous experience, I know you are more than qualified for this position from your interaction with customers in the retail field, you have excellent written and verbal communication skills, you work independently, you are organized and you are great at multitasking. You are always willing to offer help and assistance with coworkers and you have a good rapport with your past employers. This position pays very well and is a Monday-Friday position with no weekends. I honest think you should apply for the position. Please give it some thought and if you decide to apply let me know and I will put in a good word for you.

Essay --

Jackson 1 GOOD COMMUNICATION IN THE BUSINESS WORLD In today’s competitive business world, effective communication is more important than ever. Everything done in the workplace involves communication. Effective relationships with staff, clients, vendors and superiors are critical. It also has an impact on a company’s overall profitability and longevity. In a workplace environment, where many people of different backgrounds and personalities interact on a daily basis, the ability to effectively communicate becomes critical to the success of the department and the company. George Bernard Shaw said, â€Å"The single biggest problem in communication is the illusion that it has taken place.† To effectively communicate, you must â€Å"speak the language† of many others. That could be as extreme as learning a foreign language, but is usually making sure that what has been said is positively received and processed by the listener. The speaker must use proper grammar, enunciation, and vocabulary, and then evaluate the effectiveness by the listener’s reaction. In the business world, it is unlikely that o...

Ethics during Change Paper Essay

The purpose of change in the work place is to help motivate the people there and make a difference in the company. Change is needed to make improvements and better things so that a company can move forward and focus on the future. In this paper one will help the reader understand some ethical issues that organizations may face when making changes to their companies. Understanding this will help the reader identify ethical issues with in their own company when implementing change. Companies face many challenges when it comes time for change. However, ethical challenges are more difficult to figure out when it is detected. There may be many ethical issues that companies have to go through, but some are easier to focus on. One major issue can start with self-control. Even though companies have their own set of policies, rules, and other directions all ethical issues are still a problem that management has to handle. It is best that when implementing changes that the employees are still informed with the changes that will be made. Not only will change help motivate but it will also impact the employees on new knowledge within the process of change. Companies want for their employees to have self-control when it comes to making ethical decisions. Change can be overwhelming at times, not only for the people who work within the company, but everyone who plays a part in that company. Even though it can be disruptive it is best to make sure that everyone is involved. Figure out how to change the focus on making it less of a problem. The company needs to plan ahead, so that they will be ready for the different outcomes that come with innovation and change. Companies may want to give their employees a heads up on the process but may not be able to until a certain point of the process is met. Changes will affect the way the employees do their jobs but management needs to speak up so that they do not become a disruption in the change process that they are trying to implement. This can be a down fall for some companies because giving information to soon may affect the process of change. Communication also plays a role in the process of change and dealing with ethics. An open line  of communication is best to help communicate the nee ds and wants for change within that organization. When communicating with the employees and staff this helps build the trust between the two. When companies are not honest and giving the employees the information about the change they are trying to make it makes it difficult for the employees to trust when the change is implemented because they were not aware of what was going on. Not letting the staff know what’s going on can cause problems of trust, how they do their jobs, and the way that they perform. Team work is essential because the ethical behavior to the employees and community can help the business more than they know. Participating in the process of change can help the company see where their future may be when they work for the greater purpose in making these changes. These changes that will be made for companies can benefit everyone in the organization. Rewarding the ones who helped with the change process and treating them in an ethical manner, will bring greater results for them in the long run. Ways to resolve ethical issues can be to educate the employees on a code of ethics and how they want their company to be run. Giving them examples and leading with confidence can help them resolve common ethical dilemmas. Companies need to be clear in what they want and show their employees ethical behavior through their eyes. Let the employees know what is expected when ethical problems appear give them the chance to show them that they know how to handle the situation. Again reward those who make the good ethical decisions. There are plenty of ethical challenges companies will come across throughout time. The way to understand how to address these problems, and each of the different challenges, is to think of the source of the problems and how the company is affected by those results. Companies want to come out on top and show that they are better than their competitors. If an organization focuses on the right things such as ethics and how they run their company they will come out on top. Making sure that all the factors above are address when situations in the change process accrue then they should be able to handle the issues with no problem. Problems accrue when the management is not ethically tr ained and when they don’t know how to focus on the right subjects. All focus during the change process needs to be on the employees and how the change will affect the company.

Unemployment and Its Effect on the Economy and Society

Unemployment is an ongoing problem throughout the world. One may asked, what is unemployment? It is the number of persons who are willing and able to work but are unable to find jobs. Unemployment is harmful to a country because it imposes costs on a Society. The cost of employment to a nation can be categorised under three heading, namely  · The Social Cost  · The Cost to the Exchequer  · The Economic Cost The Social Cost of Unemployment The social cost of involuntary unemployment is incalculable. For an individual, the demoralising effect that it can have clearly depends upon whether the period of unemployment is short term or long term. Short term unemployment may have no serious effect on an individual whilst long term unemployment can†¦show more content†¦This means that society has experienced a lower standard of living than would have been possible without rising level of unemployment. The loss of potential output resulting from involuntary unemployment is clearly a serious matter for an economy. Resources which are willing and able to work in order to raise the rate of output and to boost living standards are failing to be employed. This is a true waste of resources. It is not so clear, however, whether the loss of potential output through voluntary unemployment is so serious. It may simple mean that be that more people are taking advantage of higher social security benefits to spend more time searching for suitable jobs. There are numerous causes to the problem of unemployment which may vary from country to country. Amongst them are Natural unemployment The level of natural unemployment can be defined as the number of persons who are employed even when the labour market is in long-run equilibrium that is when the total demand for labour is equal to the supply of labour at the prevailing level of real wage rates. In this situation, people may be unemployed because:  · they are between jobs and are taking time to search for the most appropriate job with the highest wage(search unemployment)  · the industry in which they have traditionally worked have experienced a structural decline or has been influenced by technological advances (structural unemployment)  · there has been a seasonalShow MoreRelatedCauses And Effects Of Unemployment1611 Words   |  7 Pagesï » ¿ Causes and Effects of Unemployment Travis Epling Strayer University ENG 105 Jeanette Trammel 9/14/14 Causes and Effects of Unemployment There are many reasons for unemployment in the United States and around the world. Some of these causes are created by the individual and others are out of their control. No matter what the cause for unemployment, it has a devastating effect on the individual, family, and economy. Unemployment defined by the Encyclopedia Britannica is the conditionRead MoreMinimum Wage And Its Effect On The Economy1015 Words   |  5 PagesThe In today’s society, people face to many serious issues which affect the society both in a positive and negative ways such as increasing the employment rate and increasing the unemployment rate. The increasing of unemployment rate is caused by some reasons, and one of the problem that causes the high unemployment rate is the issue of minimum wage. Depending on the states in U.S., the price of minimum wage is different, but the low minimum wage may cause the economic condition worse. MinimumRead MoreThe Positive and Negative Aspects of Job Migration943 Words   |  4 Pagesseeks to evaluate the positive and negative impacts of labor migration. This research will begin by evaluating the economic effects of job migration it will then proceed to investigate the social effects. In the process it will be highlighted that the impacts of migration are balanced. Main body Economical effects Job migration has negative and positive impacts on economy. All countries take taxes from migrants. Migrants fail to pay taxes in their home country, but faced with the need to pay theRead MoreIntroduction. The Rising Unemployment Has Generated Challenges1381 Words   |  6 PagesIntroduction The rising unemployment has generated challenges in low income communities. Unemployment involves a situation where people in a particular community are actively seeking employment but the employment rates are low. The increased rates of unemployment are contributed to by factors such as recession periods that adversely affects the economy. Impacts on the economy in turn affect the labor force leading to loss of employment and reducing the rates of employment opportunities in the countryRead MoreThe Regulation Of Minimum Wage1055 Words   |  5 PagesThe Regulation of Minimum Wage In today’s society, people face to many serious issues which affect the society both in a positive and negative ways such as increasing the employment rate and increasing the unemployment rate. The increasing of the unemployment rate is caused by some reasons, and one of the problems that causes the high unemployment rate is the issue of the minimum wage. Depending on the states in the U.S., the price of minimum wage is different, but the low minimum wage may causeRead MoreEvaluate Alternative Measures Which Can Be Used to Reduce Unemployment.696 Words   |  3 PagesUnemployment refers to the numbers of people not working and can be measured by the claimant count and labour force survey. There are different types of unemployment and each of them requires different policies to overcome them.†¨Ã¢â‚¬ ¨ Firstly Cyclical unemployment or demand deficient unemployment is caused by a lack of spending throughout the economy and generally affects all sectors of the economy because spending is falling. To overcome this, the government needs to introduce policies which seekRead More The Federal Reserve System Essay example1453 Words   |  6 Pagesand growth of the economy, and moderate long-term interest rates. The Fed employs Monetary Policy in an effort to manage both the money supply and interest rates while stimulating the economy to operate close to full employment. One school of thought called Monetarism believes that the Federal Reserve should simply pursue policies to eliminate inflation. Zero inflation may help the market to avoid imbalances, stabilize the business cycle, and promote steady growth in our economy. On the other handRead MoreEconomic Crisis: Effects on the Economy1486 Words   |  6 PagesRunning Head: ECONOMIC CRISIS: EFFECTS ON THE ECONOMY 2 Abstract The United States is obviously in a state of economic despair. This essay has supporting facts that prove the economy is definitely not on the mend. The public has been led to believe that this downward spiral is almost over. What will be proven in this paper is that foreclosure rates are still dramatically increasing and that the total in unemployment rates is deceiving. Without more jobs, consumersRead MoreUnemployment And Its Effects On America926 Words   |  4 Pagesquarter month 2014 to date† (Bolen). Unemployment is the one of the biggest poverty problems in America. But what is unemployment? Unemployment is described as when people are looking for job within the past four weeks and can’t find work, however, it can also mean an economic condition that is marked by the fact that individuals actively seeking jobs remain unhired (Unemployment Definition). Unemployment affects the United States economic system, and the society in this nation. The United StatesRead MoreThe Positive Relationship Between Inflation And Inflation1067 Words   |  5 Pagesunexpected effect on the economy. One of these examples can be observed when we compare inflation and unemployment rate. To establish this comparison in a short-run period of time, it will be beneficial to use the Phillip Curve. This curve can be used as a tool to represent the positive relationship between inflation and unemployment in the short-run. In order to comprehend the positive relationship between inflation and unemployment first, we must know what inflation is, how we define unemployment, and

The American Dream - 996 Words

My definition of American Dream If we ask most Americans what is the American Dream? the common answers are to become successful, rich, owning houses, cars and etc. In other countries, many people see America as a land of opportunities for a better life and that is the reason why they come here. Every individual who come to America have their goals or dreams that they want to fulfill in life that they can not fulfill in their own country. In another word, their American dream are to have better life for themselves and their children, better education, more rights, and freedoms. For instance, my parents came to America so we could have a better life and better education that we could not have in our country. That was their definition of†¦show more content†¦To sum up, these are the reasons why having a better education and being well educated is one of my definitions of American dreams. Having the rights and freedoms of American citizens is another one of my definitions of the American dream. In America, to be able to express oneself and their opinion, vote and have freedom of religion is a great privilege. For example, in my countries, people could not even express themselves or their opinion about the government. It does not matter if they like the government or not because they were not given a choice. They can not even choose who is going to be the leader of their government because they did not have the right. Also, they must worshipped what the government wanted them to worship because they did not have the freedom of religion. In another word, the government has all the power, and whoever go against it could end up with terrible consequences. In summary, these are the reasons why having the rights and freedoms of an American citizen is my meaning of the American dream. To be successful is the biggest definition of the American dream. For me, to be successful is to be able to have and own a nice house and a nice car, have a good paying job that I like and have a happy family. For example, when my family first moved in America, we were so poor that we did not have a car. My dad only has one bicycle that he went to work with in every season,Show MoreRelatedImmigrants And The American Dream1362 Words   |  6 PagesImmigrants and the American Dream In the article â€Å"The American Dream†, by James Truslow Adams in The Sundance Reader book, he stated that the American dream is that dream of a land in which life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement. It is a difficult dream for the European upper classes to interpret adequately, and too many of us ourselves have grown weary and mistrustful of it. It is not a dream of motor cars and highRead MoreThe American Dream By Kimberly Amadeo1637 Words   |  7 PagesNowadays, a large number of people migrate to the United States to work and achieve the American Dream. According to the Article â€Å"What is the American Dream?† by Kimberly Amadeo, â€Å"The American Dream was first publicly defined in 1931 by James Truslow Adams in Epic of America. Adam’s often-repeated quote is, ‘The American Dream is that dream of land in which life should be better and richer and fuller for everyon e, with opportunity for each according to ability or achievement.’† There are many peopleRead MoreAnalysis Of The Movie The American Dream 754 Words   |  4 Pages Nyreel Powell Ms. Jones American Literature 1 June 2015 The American dream in A Raisin in the Sun Have you ever had a dream and it didn’t come how you wanted it to be? Have you ever had accomplishments that you wanted to achieve but people were getting in the way of them? The four main characters in this book all have good dreams but there are people in the way of getting to those dreams or their dream is too high to accomplish. A Raisin in the Sun a play written by Lorraine Hansberry, andRead MoreSister Carrie and the American Dream1618 Words   |  7 PagesThe American Dream is surely based on the concept of â€Å"Life, Liberty and the Pursuit of Happiness† but it is above all, a matter of ambition. James Truslow Adams, an American writer and historian, in 1931 states: life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement†, which not only points towards a better standard of living for Americans but also denounces a degree of greed in the US society. Ambition not only â€Å"killed the catâ₠¬  butRead MoreGrapes Of Wrath And The American Dream1644 Words   |  7 PagesThe idea of the American Dream is ever changing depending on the person and the time of life that person is in. Although the main ideas of the American Dream remain the same to be educated, economically sound, healthy, to have a family, and equal rights. Many great films and works of literature were created to show case all the different ideas people have for their American Dream. The film â€Å"Grapes of Wrath† directed by John Ford and the poem â€Å"I Will Fight No More Forever† by Chief Joseph, both depictRead More Destruction of the American Dream Essay2145 Words   |  9 PagesDestruction of the American Dream I’ve talked about it in the past, the destruction of the American Dream. Always, there have been papers, writings, and thoughts that quantify a particular section of its ultimate demise, be it due to money, education, or sexuality. Maybe the destruction cannot be viewed as a singular event or cause. Perhaps instead it must be examined as a whole process, the decay and ultimate elimination of a dream. Self destruction, if you will†¦ Mr. Self Destruct Read MoreSuccess As One Of The American Dream1137 Words   |  5 PagesApril 2015 Success as One of The American Dream When we hear the word â€Å"success†, we often think of wealth and money. To some people, the embodiment of being success is earning a lot of money. In fact, the concept of success is primarily based on how much money a person earns. However, each person views the definition of success differently. One way to define success is something that has more to do with flash than it does with substance. John Wooden, an American basketball player and coach viewRead MoreJim Cullen And The American Dream2081 Words   |  9 Pages The American Dream, as defined by Cullen, is starting your goal off with a little and ending with more; it s like a business, you invest in it in order to gain more money. Usually, people will define the American Dream as being able to achieve your goal because everyone is offered opportunities. Cullen does acknowledge that people are born with different opportunities, so he talks about the good life. The good life describes different factors that determine your opportunities. Throughout the otherRead MoreFactors Influencing The American Dream1834 Words   |  8 Pagesindividual to succumb or to not succumb to the seductions of crime. These three factors are brilliantly portrayed in the television show, Breaking Bad and the novel, The Stick Up Kids. The American Dream is what many American citizens strive for. However, not all of those citizens are able to achieve the American Dream through a legal pathway. The reason an indivudal may not being able to do so is because of his or her background factors. It is important to note that background factors are a fractionRead MoreShark Tank And The American Dream1755 Words   |  8 PagesShark Tank and The American Dream The TV show Shark tank embodies everything the American dream represents. The show obtains successful Entrepreneurs ready to invest their own money into other Americans wanting to be just like them, reaching the American dream and become a successful entrepreneur. The show presents entrepreneurs working towards the goal of creating a business to not only gain wealth but also change the way we live today. The show is to keep the American dream alive and well while